High Blood Urea: Causes, Symptoms, and Treatments

The urea It is a by-product derived by the human body when the liver is assimilating proteins and nitrogen compounds. It was discovered in 1932 by HA Krebs Y K. Henseleit, who noted that when ornithine or arginine was added, the liver began to produce a greater amount of ammonia.

Its place of origin is the liver and is the result of a cycle known as the “urea cycle”. This substance is usually expelled from the body through urine, but when urea levels get too high in the blood It can bring terrible consequences such as kidney failure, liver failure, nervous system disorders, heart failure problems, among others.

What causes high blood urea?

There are many diseases that can cause the amount present in the blood to increase markedly, for example, hypertension, kidney and liver failure, cirrhosis, gout or diabetes. To determine the levels of urea present in the body, doctors go to blood tests to know the levels of urea and creatinine, which allows them to know in what condition the kidneys are and if they are draining properly. Some other reasons that can cause it to increase can be:

  • A diet with too much protein
  • Dehydration problems
  • Bleeding in the gastrointestinal system
  • Exercising too hard and regularly

What are the symptoms of high blood urea?

Through some symptoms, it can be intuited that this waste substance produced in the liver is not being expelled correctly from the body and that therefore it has been accumulating in the blood, these symptoms are:


This symptom is accompanied by a feeling of continuous thirst in which the patient will feel that his mouth is dry regardless of the type and amount of liquid he ingests. If we add to this the lack of appetite, we could be facing a very clear sign that urea is accumulating in the blood.


Although many people may believe that having low blood pressure can be a good thing, it is a very serious mistake. This can be one of the main symptoms of a disorder known as uremia.

Renal problems

The presence of very high levels of urea in the body it can cause the kidneys to be damaged, leading to actual failure.


This is an unconventional type of bad breath, since the affected person will have a bad taste in the mouth and their oral cavity will smell like ammonia. This in many cases does not come alone, but with it ulcers can appear in different parts of the mouth.

Tiredness and weakness

There are many factors that can cause tiredness and weakness, but if they are accompanied by any of the other symptoms, they may be due to high urea levels.

Gastrointestinal tract disorders

Generally, if a person has elevated urea values, they begin to experience gastrointestinal problems such as vomiting and diarrhea.

How to reduce blood urea levels?

Normally, the levels of this by-product are below 40 mg / dl, but they are said to be high levels when found above 50 mg / dl. If the levels are above normal, the first thing that must be done to reduce them is to identify the origin, if it is a disease they will automatically decrease when it is treated, or if it is due to food, just changing the diet will be enough.

In summary

Having urea levels that are too high can be dangerous, so you always have to go to the doctor and have routine tests. Also, following a proper diet can help levels stay optimal.

Also see what it means to have low urea.

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