Gamma GT high: What does it mean?

The Gamma Glutamyl Transferase, better known as Gamma GT or GGT, It is an enzyme of the liver cells, although it exists in other organs. GGT is also involved in the breakdown of toxins and drugs, as well as in the production of essential amino acids for the brain and heart.

Normally, this enzyme is present in the liver, except when some alteration occurs, then it is filtered into the blood and can be detected with a blood test.

When there is any suspicion of liver problems, specialists order an analysis to measure the levels of Gamma Glutamyl Transferase.

Have the Gamma GT high, which means, without a doubt, is that you should seek a medical consultation, because there is an alert of possible problems with your liver.

Gamma GT or GGT

The main function of the Gamma GT enzyme is to metabolize glutathione, one of the main antioxidants produced by the body. It also executes the process of transferring glutathione to other amino acids, contributing to cellular homeostasis and strengthening the immune system.

Normal values

The normal values ​​of Gamma Glutamyl Transferase in blood are:

  • For Men, between 0 and 51 units per liter.
  • For Women, between 0 and 35 units per liter.

These GGT values ​​are referential and can be influenced by age, weight, diet, exercise, pregnancy, and medications taken.

What does a tall Gamma GT mean?

A high Gamma GT means there are liver problems or liver associated disease is present. Although it is not very common to have a Gamma GT or High GGT, the doctor will need to do more studies to establish what is causing this increase in the enzyme.

You can also take a look at the article on the Low MCHC.

Among the factors that usually cause a high GGT in blood we have:

Liver disease

The liver diseases They cause fibrosis or scarring of the liver due to abuse of alcohol, drugs or others, increasing the values ​​of Gamma Glutamyl Transferase. Cirrhosis, hepatitis, and fatty liver are some of the most common diseases that affect liver function.

Drug consumption

There are medicines that damage the liver and interfere with its proper functioning, such as certain anticonvulsant drugs, many antibiotics, and some contraceptives.

For example, phenobarbital is a narcotic, which serves as a sedative and anxiolytic and causes increased levels of GGT. On the other hand, alcohol consumption also causes an increase in Gamma Glutamyl Transferase values.


Some American universities such as Cornell and of North Carolina have been studying the effects of arteriosclerosis in the main organs of the body. These studies have revealed that arteriosclerosis damages the lungs, liver, kidneys, and even the heart.

Mellitus diabetes

People with Mellitus diabetes they are at higher risk of accumulating fat in the liver, a condition known as nonalcoholic fatty liver. Although this condition does not cause symptoms, it increases the possibility of inflammation or scarring of the liver, which increases GGT.

Smoking and alcoholism

Addictions like smoking and the alcoholismIn most cases, they cause liver cirrhosis, which causes scarring of the liver, increasing GGT.

Heart failure

The In heart failure It is a condition where the heart is not able to supply the required blood throughout the body. Some studies have found a relationship between this condition and high GGT.


The cholestasis is a condition caused by an obstruction in the flow of bile from the liver to the duodenum, which slows or stops it altogether. This obstruction can cause liver infections, inflammation, cysts and even liver tumors or cancer, increasing GGT values.

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